Akt
Akt (Protein kinase B (PKB)) is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.
Akt regulates cellular survival and metabolism by binding and regulating many downstream effectors, e.g. Nuclear Factor-κB, Bcl-2 family proteins and MDM2.
Akt could promote growth factor-mediated cell survival both directly and indirectly. BAD is a pro-apoptotic protein of the Bcl-2 family. Akt could phosphorylate BAD on Ser136, which makes BAD dissociate from the Bcl-2/Bcl-X complex and lose the pro-apoptotic function. Akt could also activate NF-κB via regulating IκB kinase (IKK), thus result in transcription of pro-survival genes.
Akt1 has also been implicated in angiogenesis and tumor development.
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Honokiol, a low molecular weight natural product isolated from the bark of magnolia officinalis, possesses potent anticancer activities which is chiefly via the inhibition of AKT and mitogen-activated protein kinase (MAPK) phosphorylation. Honokiol是木兰的有效成分，抑制Akt磷酸化，且促进ERK1/2磷酸化。
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AZD5363能够有效抑制Akt1/Akt2/3，IC50分别为3 nM/8 nM/8 nM，对P70S6K/PKA也具有相似的抑制效果，对ROCK1/2具有较低的抑制活性。
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AT7867是一种有效的，ATP竞争性的Akt1/2/3和p70S6K/PKA抑制剂，IC50分别为32 nM/17 n/47 nM和85 nM/20 nM，对AGC激酶家族以外几乎没有抑制活性。
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CCT128930是ATP竞争性Akt2抑制剂，IC50为6 nM，比对其它PKA相关激酶的抑制性强28倍以上。
More
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Afuresertib是pan-Akt高效抑制剂，临床1期。
More
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Honokiol, a low molecular weight natural product isolated from the bark of magnolia officinalis, possesses potent anticancer activities which is chiefly via the inhibition of AKT and mitogen-activated protein kinase (MAPK) phosphorylation. Honokiol是木兰的有效成分，抑制Akt磷酸化，且促进ERK1/2磷酸化。
More
-
AZD5363能够有效抑制Akt1/Akt2/3，IC50分别为3 nM/8 nM/8 nM，对P70S6K/PKA也具有相似的抑制效果，对ROCK1/2具有较低的抑制活性。
More
-
AT7867是一种有效的，ATP竞争性的Akt1/2/3和p70S6K/PKA抑制剂，IC50分别为32 nM/17 n/47 nM和85 nM/20 nM，对AGC激酶家族以外几乎没有抑制活性。
More
-
CCT128930是ATP竞争性Akt2抑制剂，IC50为6 nM，比对其它PKA相关激酶的抑制性强28倍以上。
More
-
Afuresertib是pan-Akt高效抑制剂，临床1期。
More
